Issa Doumbia scored the only goal as Sporting beat Shakhtar Donetsk at Stamford Bridge under interim coach Tiago Fernandes. Reports in Portugal say Lyon coach Paulo Fonseca will take over.
West Ham have sacked Nuno Espírito Santo after a 3-1 home defeat to West Brom left them eighth in the Championship. Mark Noble takes temporary charge for the trip to Cardiff.
Roma have scored 21 goals in their last six games and travel to Old Trafford on Tuesday. Michael Carrick’s United have lost their last three and have not won since September.
Porto have won all ten league games in Portugal but lost all three in Europe. Napoli arrive with three points, a long injury list and De Bruyne a doubt.
Betis have won all three of their Champions League games for the first time. On Wednesday Manuel Pellegrini’s side visit Borussia Dortmund, who have six points.
Galatasaray have three points from three games and Stuttgart have seven. The two clubs meet for the first time at RAMS Park on Tuesday evening.
Inter and Feyenoord both have three points from three Champions League games. Inter play in Rotterdam without Lautaro Martínez and the suspended Alessandro Bastoni.
José Mourinho’s Real Madrid have won all three Champions League games so far. In Athens on Wednesday, Bellingham can beat an Iker Casillas record and Luka Jović faces his old club.
Thierno Barry scored after a goalkeeping mistake as Everton won 1-0 at St James’ Park. Everton move up to seventh, while Newcastle and Matthias Jaissle stay 13th.
Paris Saint-Germain are unbeaten in 13 Champions League games, equal to the club record. They play Villarreal on Tuesday without Ousmane Dembélé and Marquinhos.
